crRASP is a novel conjugate of all-trans-retinoic acid and the polyamine spermine, designed to overcome the toxicity and delivery limitations of traditional retinoids.

Key Properties

  • Non-toxic, non-teratogenic, non-mutagenic
  • No skin or eye irritation, no phototoxicity
  • Strong anti-inflammatory and immunosuppressive activity
  • Demonstrated activity in dermatology and oncology models

Manufacturing

A simple, scalable two-step process:

  • Ambient conditions
  • Atom-economic
  • Easily upscalable
  • >98% purity (analytical grade)

Intellectual property

  • EU Patent: EP3878840A1 — in final examination
  • GR Patent: GR20200100131 —Granted

Key Insights

Inflammation
4× more effective than tretinoin in paw-edema model
Antioxidant
Inhibition of lipoxygenase, while tretinoin had no effect
Immunomodulation
Reduces IL-2 and IFN-γ in CD4⁺/CD8⁺ T cells
Cancer
Selective cytotoxicity against prostate cancer cells
Angiogenesis
Superior inhibition vs. tretinoin
Safety
No adverse effects in two-generation rat reproductive tox study
innovate with crRASP


Now in Pre-Clinical Evaluation Phase. Contact Us to Explore Investment Opportunities.

Contact us

Key Publications:

  1. Petridis T. et al.,Investigation on Toxicity and Teratogenicity in Rats of a Retinoid-Polyamine Conjugate with Potent Anti-Inflammatory Properties.Birth Defects Res (B) 107 (2016) 32-44. DOI: 10.1002/bdrb.21170
  2. Grafanaki K. et al.,Pharmacoepigenomics circuits induced by a novel retinoid-polyamine conjugate in human immortalized keratinocytes.Pharmacogenomics J. (2021). DOI: 10.1038/s41397-021-00241-9
  3. Hadjipavlou-Litina D. et al.,Does conjugation of antioxidants improve their antioxidative/anti-inflammatory potential?Bioorg Med Chem. 18 (2010) 8204-8217. DOI: 10.1016/j.bmc.2010.10.012
  4. Papaioannou D., Drainas D., Tsambaos D.WO 2004/018001 A1; US 7,517,913 B2.
  5. Vourtsis D. et al.,Effect of an all-trans-retinoic acid conjugate with spermine on viability of human prostate cancer and endothelial cells in vitro and angiogenesis in vivo.Eur J Pharmacol. 698 (2013) 122-130. DOI: 10.1016/j.ejphar.2012.11.007
  6. Magoulas G. et al.,Preparation of spermine conjugates with acidic retinoids with potent ribonuclease P inhibitory activity.Eur J Med Chem. 44 (2009) 2689-2695. DOI: 10.1016/j.ejmech.2009.01.001